2009 Fiscal Year Final Research Report
Searching for susceptible genes acting metabolic disorders induced by a high-fat diet
| Project/Area Number |
20780093
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
KOBAYASHI Misato Nagoya University, 大学院・生命農学研究科, 助教 (20456586)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 高脂肪食 / 脂質代謝 / 脂肪肝 / コンソミック / マウス |
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| Research Abstract |
To identify susceptible genes for diet-induced obesity, dyslipidemia, and impaired glucose metabolism, we used mouse chromosome substitution strains (consomic) which is a powerful animal model for genetic analyses. Consomic mouse showed that gene(s) on chromosome 12 control susceptibility for high-fat diet induced not only fatty liver but also insulin resistance. In addition, we could select one candidate gene for these traits using gene expression analysis in liver.
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