2009 Fiscal Year Final Research Report
Elucidation of biofunctional expression mechanism of food polyphenols by oxidative modification of protein
| Project/Area Number |
20780101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
AKAGAWA Mitsugu Osaka Prefecture University, 生命環境科学研究科, 助教 (70405356)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHII Takeshi 静岡県立大学, 大学院・生活健康科学研究科, 助教 (50448700)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ポリフェノール / カテキン / 緑茶 / ガン / 蛋白質 / p68 |
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| Research Abstract |
In the present study, we searched for polyphenols that covalently bind to cellular proteins. A major green tea catechin, epigallocatechin-3-gallate (EGCG), was identified to bind to cellular proteins with high affinity. The regulation mechanism of protein function by the binding of EGCG was examined. We also identified cellular protein targets of EGCG in several functional categories including energy metabolism, glycolysis, chaperone, and RNA processing. The binding of EGCG to the target protein was suggested to be closely involved in anti-cancer effect of EGCG.
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[Journal Article] Catechol-type polyphenol is a potential modifier of protein sulfhydryls: Development and application of a new probe for understanding the dietary polyphenol actions2009
Author(s)
Ishii, T., Ishikawa, M., Miyoshi, N., Yasunaga, M., Akagawa, M., Uchida, K., Nakamura, Y.
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Journal Title
Chem. Res. Toxicol. 22(10)
Pages: 1689-1698
Peer Reviewed
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[Journal Article] Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation2008
Author(s)
Ishii, T., Mori, T., Tanaka, T., Mizuno, D., Yamaji, R., Kumazawa, S., Nakayama, T., Akagawa, M.
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Journal Title
Free Radic. Biol. Med. 45(10)
Pages: 1384-1394
Peer Reviewed
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