Studies on the esophageal motility in the gastroesophageal reflux disease-model animals

2010 Fiscal Year Final Research Report

• Project/Area Number: 20780206
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Gifu University
• Principal Investigator: SHIINA Takahiko Gifu University, 応用生物科学部, 准教授 (90362178)
• Project Period (FY): 2008 – 2010
• Keywords: 食道 / 胃食道逆流症 / 疾患モデル / 神経 / 横紋筋

Research Abstract

To clarify the pathogenesis of Gastroesophageal reflux disease (GERD), the esophageal motility control in the house musk shrew (Suncus murinus), which is a new GERD-model animal. Morphological studies revealed that the inner and outer muscle layers of the shrew esophagus are entirely composed of the striated muscles. Functional examinations indicated that the esophageal motility in the shrew is regulated by both extrinsic (vagal) and intrinsic neurons. Reflux of acids might activate the esophageal neurons and then alter the motor activity. Future research using the shrew will explore issues of GERD further.

Research Products

• [Journal Article] Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats. (2011)
  • Author(s): Iwami, M., Shiina, I., Hirayama, H., Shima, T., Takewaki, T., Shimizu Y.
  • Journal Title: J.Nat.Med. 65 Pages: 89-94
  • Peer Reviewed
• [Journal Article] Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus. (2010)
  • Author(s): Shiina, T., Shima, T., Hirayama, H., Kuramoto, H., Takewaki, T., Shimizu, Y.
  • Journal Title: Eur.J.Pharmacol. 628 Pages: 202-206
  • Peer Reviewed
• [Journal Article] Contractile properties of esophageal striated muscle : comparison with cardiac and skeletal muscles in rats. (2010)
  • Author(s): Shiina, T., Shima, T., Masuda, K., Hirayama, H., Iwami, M., Takewaki, T., Kuramoto, H., Shimizu, Y.
  • Journal Title: J.Biomed.Biotech. vol.2010 Pages: Article ID 459789, 7
  • Peer Reviewed
• [Journal Article] The neural regulation of the mammalian esophageal motility and its implication for esophageal diseases. (2010)
  • Author(s): Shiina, T., Shima, T., Worl, J., Neuhuber, W.L., Shimizu, Y.
  • Journal Title: Pathophysiology. 17(review) Pages: 129-133
  • Peer Reviewed
• [Journal Article] Galanin modulates vagally induced contractions in the mouse esophagus. (2009)
  • Author(s): Boudaka, A., Worl, J., Shiina, T., Shimizu, Y., Takewaki, T., Neuhuber, W.L.
  • Journal Title: Neurogastroenterol.Motil. 21 Pages: 180-188
  • Peer Reviewed
• [Journal Article] Enteric co-innervation of esophageal striated muscle fibers : A phylogenetic study. (2009)
  • Author(s): Hempfling, C., Seibold, R., Shiina, T., Heimler, W., Neuhuber, W.L., Worl, J.
  • Journal Title: Auton.Neurosci. 151 Pages: 135-141
  • Peer Reviewed
• [Presentation] 嘔吐する小型実験動物スンクス(Suncus murinus)の食道の特徴 (2011)
  • Author(s): 椎名貴彦
  • Organizer: 日本病態生理学会第2回サテライトセミナー
  • Place of Presentation: 神戸
  • Year and Date: 20110000
• [Presentation] 局所神経経路によるラット食道横紋筋運動に対する抑制性制御 (2011)
  • Author(s): 椎名貴彦, 嶋剛士, 藏本博史, 志水泰武
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 誌上にて開催
  • Year and Date: 20110000
• [Presentation] 嘔吐する小型実験動物スンクスの食道筋構造と神経支配 (2010)
  • Author(s): 椎名貴彦, 平山晴子, 嶋剛士, 志水泰武
  • Organizer: 第20回日本病態生理学会大会
  • Place of Presentation: 奈良
  • Year and Date: 20100000
• [Presentation] スンクス食道の形態学的および薬理学的特徴 (2010)
  • Author(s): 椎名貴彦, 嶋剛士, 藏本博史, 武脇義, 志水泰武
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 20100000
• [Presentation] ラット食道横紋筋の収縮特性および内在神経系による運動調節機構 (2010)
  • Author(s): 椎名貴彦, 武脇義, 志水泰武
  • Organizer: 第149回日本獣医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20100000
• [Presentation] 新生子ラット食道 筋に対する神経支配および収縮制御機構 (2010)
  • Author(s): 椎名貴彦, 中森智昭, 平山晴子, 嶋剛士, 藏本博史, 志水泰武
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 20100000
• [Presentation] ハムスター食道横紋筋における神経筋接合部の形態および機能的特徴 (2010)
  • Author(s): 椎名貴彦,Jurgen Worl,Winfried Neuhuber,嶋剛士,志水泰武
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広
  • Year and Date: 20100000
• [Presentation] ラット食道運動におけるカプサイシン感受性神経の役割 (2009)
  • Author(s): 椎名貴彦, 嶋剛士, 武脇義, 志水泰武
  • Organizer: 第19回日本病態生理学会大会
  • Place of Presentation: 埼玉
  • Year and Date: 20090000
• [Presentation] Modulatory actions of tachykinins on the striated and smooth muscle motility in the rat esophagus. (2009)
  • Author(s): Shiina, T. , Shima, T., Hirayama, H., Boudaka, A., Worl, J., Neuhuber, W.L., Takewaki, T., Shimizu, Y.
  • Organizer: The XXXVI International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090000
• [Presentation] Neuronal regulation of the esophageal motility in Suncus murinus (a house musk shrew). (2009)
  • Author(s): Shiina, T ., Worl, J., Neuhuber, W.L., Shima, T., Takewaki, T.. Shimizu, Y.
  • Organizer: 6th Congress of the International Society for Autonomic Neuroscience (ISAN 2009)
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20090000
• [Presentation] スンクス(Suncus murinus)食道運動における神経性制御 (2009)
  • Author(s): 椎名貴彦, Jurgen Worl, 平山晴子, 嶋剛士, Winfried Neuhuber, 武脇義, 志水泰武
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 20090000
• [Presentation] ラット食道粘膜筋板平滑筋の収縮を制御する神経伝達物質 (2008)
  • Author(s): 椎名貴彦, 嶋剛士, バウダカ アッマール, 武脇義, 志水泰武
  • Organizer: 第55回中部日本生理学会大会
  • Place of Presentation: 愛知
  • Year and Date: 20080000
• [Remarks] ホームページ等
  • URL: http://wwwl.gifu-u.ac.jp/~yshimizu/physiologv/toppage.html