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2009 Fiscal Year Final Research Report

Mechanisms of luteolysis via local GnRH as a follicular developing signal.

Research Project

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Project/Area Number 20780210
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionKitasato University

Principal Investigator

YONEZAWA Tomohiro  Kitasato University, 獣医学部・獣医学科, 講師 (10433715)

Project Period (FY) 2008 – 2009
Keywordsゴナドトロピン放出ホルモン / アネキシンA5 / 黄体退行 / メタスチン / アポトーシス / 卵巣 / 性周期 / エストロジェン
Research Abstract

Corpora lutea in rats start to regress in the afternoon of diestrus 2. In the present study, metastin and gonadotropin releasing hormone were expressed stage-specifically, which was caused by estrogen from next-developing follicles. These findings could make contributions to avoidance of breeding disorders and fertility treatments.

  • Research Products

    (28 results)

All 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (17 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] The mechanism of GH pulse generation; involvements of sex steroids and/or NPY.2010

    • Author(s)
      Yonezawa T
    • Journal Title

      Proc Japan Soc Animal Nutr Met 54

      Pages: 13-24

    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of annexin a5 in the mammary gland of rats: up-regulation of expression by pup removal.2010

    • Author(s)
      Rieanrakwong D, Yonezawa T, Kurusu S, Kawaminami M
    • Journal Title

      J Vet Med Sci 72

      Pages: 19-22

    • Peer Reviewed
  • [Journal Article] Group IVA phospholipase A(2) activity may mediate prostaglandin F(2alpha)-induced luteal regression in pseudopregnant rats.2009

    • Author(s)
      Kurusu S, Tokunaga N, Yonezawa T, Kawaminami M
    • Journal Title

      Prostaglandins Other Lipid Mediat 90

      Pages: 55-62

    • Peer Reviewed
  • [Journal Article] Structural regression of the rat corpus luteum of pregnancy: relationship with functional regression, apoptotic cell death, and the suckling stimulus.2009

    • Author(s)
      Kurusu S, Suzuki K, Taniguchi K, Yonezawa T, Kawaminami M
    • Journal Title

      Zoolog Sci 26

      Pages: 729-734

    • Peer Reviewed
  • [Journal Article] Differential regulation of phospholipase A(2) activity and prostaglandin E(2) synthesis in activated and non-activated corpora lutea of lactation by the presence and absence of suckling stimulus in rats.2009

    • Author(s)
      Kurusu S, Kamikubo M, Yonezawa T, Kawaminami M
    • Journal Title

      Prostaglandins Other Lipid Mediat 90

      Pages: 26-30

    • Peer Reviewed
  • [Journal Article] Inhibition of ovulation by a lipoxygenase inhibitor involves reduced cyclooxygenase-2 expression and prostaglandin E2 production in gonadotropin-primed immature rats.2009

    • Author(s)
      Kurusu S, Jinno M, Ehara H, Yonezawa T, Kawaminami M
    • Journal Title

      Reproduction 137

      Pages: 59-66

    • Peer Reviewed
  • [Journal Article] 第24回日本下垂体研究会の仕掛け2009

    • Author(s)
      米澤智洋
    • Journal Title

      比較内分泌学 35

      Pages: 333-334

  • [Presentation] Multiple protective effects of locally administered inhibitors of group IVA phospholipase A2 and cyclooxygenase-2 on pseudopregnant rat corpus luteum from prostaglandin F2α-induced regression.2010

    • Author(s)
      Kurusu S, Sonoda N, Nakahara M, Yonezawa T, Kawaminami M
    • Organizer
      14th International Congress of Endocrinology (ICE2010)
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-03-29
  • [Presentation] アネキシンA5ノックアウトマウスの生殖機能2009

    • Author(s)
      西村育宏, ドワンザイ・リエンラクオン, 米澤智洋, 久留主志朗, 武藤顕一郎, Ernst Poschl, 汾陽光盛
    • Organizer
      第148回日本獣医学会
    • Place of Presentation
      鳥取大学
    • Year and Date
      2009-09-25
  • [Presentation] Metastin regulation of gonadotropin releasing hormone (GnRH) production in the mast cell.2009

    • Author(s)
      Rieanrakwong D, Yonezawa T, Kurusu S, Hasegawa Y, Kawaminami M
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-09-11
  • [Presentation] Prostaglandin (PG) F2α誘導性の偽妊娠ラットの黄体退行における黄体内因性PGの役割:phospholipase A2及びcyclooxygenase阻害薬の局所投与の効果2009

    • Author(s)
      薗田憲史, 中原理人, 米澤智洋, 久留主志朗, 汾陽光盛
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-09-11
  • [Presentation] ラット性周期黄体に発現するゴナドトロピン放出ホルモンはBaxとBcl-2の発現を制御して黄体のアポトーシスを誘導する2009

    • Author(s)
      小形次人, 米澤智洋, 久留主志朗, 汾陽光盛
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-09-11
  • [Presentation] ラット性周期黄体で産生される性腺刺激ホルモン放出ホルモンはプロラクチンの黄体刺激作用の感受性を低下させる2009

    • Author(s)
      米澤智洋, 坂田恭平, 久留主志朗, 長谷川喜久, 汾陽光盛
    • Organizer
      第24回日本下垂体研究会
    • Place of Presentation
      青森県
    • Year and Date
      2009-08-27
  • [Presentation] アネキシンA5ノックアウトマウスの表現型解析2009

    • Author(s)
      西村育宏, ドワンザイ・リエンラクオン, 米澤智洋, 久留主志朗, 武藤顕一郎, 汾陽光盛
    • Organizer
      第24回日本下垂体研究会
    • Place of Presentation
      青森県
    • Year and Date
      2009-08-27
  • [Presentation] Hypogonadal (hpg)マウスを用いた性腺刺激ホルモン放出ホルモンシグナルのバイオマーカーとしてのアネキシンA5の可能性2009

    • Author(s)
      渡邊あい子, 米澤智洋, 久留主志朗, 長谷川喜久, 汾陽光盛
    • Organizer
      第24回日本下垂体研究会
    • Place of Presentation
      青森県
    • Year and Date
      2009-08-27
  • [Presentation] Estrogen induced luteal gonadotropin releasing hormone (GnRH) causes refractoriness of newly formed corpus luteum to prolactin in the estrous cycle of rats.2009

    • Author(s)
      Yonezawa T, Kurusu S, Kawaminami M
    • Organizer
      The Endocrine Society's 91st Annual Meeting
    • Place of Presentation
      Washington, DC.
    • Year and Date
      2009-06-11
  • [Presentation] Myxovirus (influenza virus) resistance 1 (Mx1) is involved in the growth suppression of LβT2 gonadotrope cells by activin.2009

    • Author(s)
      Kawaminami M, Hashimoto T, Terashima R, Yonezawa T, Hasegawa Y, Kurusu S
    • Organizer
      The Endocrine Society's 91st Annual Meeting
    • Place of Presentation
      Washington, DC.
    • Year and Date
      2009-06-11
  • [Presentation] Mobilization of mast cells to the mammary gland is prerequisite for mammary involution after lactation: mediation of gonadotropin releasing hormone and antagonism by prolactin.2009

    • Author(s)
      Rieanrakwong D, Yonezawa T, Kurusu S, Hasegawa Y, Kawaminami M
    • Organizer
      The Endocrine Society's 91st Annual Meeting
    • Place of Presentation
      Washington, DC.
    • Year and Date
      2009-06-11
  • [Presentation] Estrogenはラット性周期黄体のMetastinと性腺刺激ホルモン放出ホルモン(GnRH)の発現を促進して黄体退行を引き起こす2008

    • Author(s)
      米澤智洋, 久留主志朗, 汾陽光盛
    • Organizer
      第101回日本繁殖生物学会
    • Place of Presentation
      九州大学
    • Year and Date
      2008-09-18
  • [Presentation] Involvement of local gonadotropin releasing hormone (GnRH) in involution of lactating mammary epithelial cells of rats.2008

    • Author(s)
      Rieanrakwong D, Yonezawa T, Kurusu S, Hasegawa Y, Kawaminami M
    • Organizer
      第101回日本繁殖生物学会
    • Place of Presentation
      九州大学
    • Year and Date
      2008-09-18
  • [Presentation] 性腺刺激ホルモン放出ホルモン(GnRH)による増殖調節2008

    • Author(s)
      汾陽光盛, 小野山一郎, 米澤智洋, 久留主志朗
    • Organizer
      第23回日本下垂体研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-30
  • [Presentation] Inhibition of ovulation by a lipoxygenase inhibitor is associated with reduced cyclooxygenase-2 expression and prostaglandin E2 production in gonadotropin-primed immature rat model.2008

    • Author(s)
      Kurusu S, Jinno M, Ehara H, Yonezawa T, Kawaminami M
    • Organizer
      Gordon research conference
    • Place of Presentation
      New Hampshire
    • Year and Date
      2008-08-07
  • [Presentation] Involvement of corpus luteum metastin in gonadotropin releasing hormone (GnRH) induced luteolysis in cycling rats.2008

    • Author(s)
      Yonezawa T, Kurusu S, Kawaminami M
    • Organizer
      The Endocrine Society's 90th Annual Meeting
    • Place of Presentation
      California
    • Year and Date
      2008-06-16
  • [Presentation] Gonadotropin releasing hormone (GnRH) receptor stimulation of Mx1 gene expression causes suppression of LβT2 gonadotrope cell growth.2008

    • Author(s)
      Kawaminami M, Onoyama I, Yonezawa T, Kurusu S
    • Organizer
      The Endocrine Society's 90th Annual Meeting
    • Place of Presentation
      California
    • Year and Date
      2008-06-16
  • [Book] アポトーシス実験法(獣医生化学実験改 訂第3版)2009

    • Author(s)
      米澤智洋(分担執筆)
    • Total Pages
      193-204
    • Publisher
      チクサン出版社
  • [Book] 繁殖内分泌に関する実習, 実験で学ぶ生理学(懇談会編)2009

    • Author(s)
      米澤智洋(分担執筆)
    • Total Pages
      82-91
    • Publisher
      学窓社
  • [Remarks]

    • URL

      http://www2.vmas.kitasato-u.ac.jp/physiology/

  • [Patent(Industrial Property Rights)] 骨成長に対するエストロゲン作用の判定法2009

    • Inventor(s)
      米澤智洋、武藤顕一郎
    • Industrial Property Rights Holder
      北里大学
    • Industrial Property Number
      特許・特願2009-109231
    • Filing Date
      2009-04-01

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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