2009 Fiscal Year Final Research Report
Molecular characterization of chicken ghrelin receptor superfamily in gut-intestinal tract system.
| Project/Area Number |
20780211
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
YAMAMOTO Ichiro Nippon Veterinary and Life Science University, 獣医学部, 助教 (00424763)
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| Project Period (FY) |
2008 – 2009
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| Keywords | モチリン / グレリン / 受容体 / GPCR / ニワトリ |
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| Research Abstract |
Motilin and ghrelin are peptide hormones involved in gastrointestinal motility. GPR38, initially cloned as an orphan receptor, is now considered a specific receptor for motilin. Previously, molecular characterization of the motilin receptor had only been performed in mammalian and fish species. We cloned cDNA for chicken motilin receptor from the duodenum and characterized its primary structure, tissue distribution, and biological activity. Our data suggest that chicken motilin receptor is largely involved in gastrointestinal functions at pre- and post-hatch periods through an intracellular signaling pathway accompanied by an increase in Ca^<2+> levels.
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[Journal Article] Hypertriglyceridemia with increased plasma insulin concentrations in cats.2010
Author(s)
Hatano Y, Mori N, Asada M, Mori A, Yamamoto I, Muranaka S, Kojima M, Kigure M, Yagishita M, Sako T, Arai T.
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Journal Title
Res Vet Sci 88
Pages: 458-60
Peer Reviewed
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