2009 Fiscal Year Final Research Report
Study on the anti-allergic DNA vaccines with nanoparticle in gut mucosal immune system
| Project/Area Number |
20780238
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Shinshu University |
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Principal Investigator |
SHIMOSATO Takeshi Shinshu University, ファイバーナノテク国際若手研究者育成拠点, 助教 (00467200)
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| Project Period (FY) |
2008 – 2009
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| Keywords | DNAワクチン / 食物アレルギー / 食品免疫学 |
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| Research Abstract |
In this study, we constructed the DNA vaccine based on the genetic information of the food allergen molecules (egg, Sova, and milk). We demonstrated that the DNA vaccine induced anti-allergic activation on the milk allergic model mice. In addition, we found that DNA vaccine induced the anti-inflammatory effects in the mice splenocytes. Exploiting this property may also prove useful in the design and production of new physiologically functional vaccine.
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