• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Final Research Report

Synthesis of eudistomin D analogues and its effects on adenosine receptors

Research Project

  • PDF
Project/Area Number 20790001
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionHokkaido University

Principal Investigator

ISHIYAMA Haruaki  Hokkaido University, 大学院・薬学研究院, 助教 (70333622)

Project Period (FY) 2008 – 2009
Keywords生薬 / 天然物化学
Research Abstract

Two analogues of eudistomin D, a β-carboline alkaloid from a marine tunicate Eudistoma olivaceum, were synthesized, and their affinity and selectivity for adenosine receptor subtypes A_1, A_<2A>, and A_<3> were examined. Both compounds exhibited the moderate affinity to the receptor A_3. On the other hand, four bis-N-n-propyl analogues in the uracil ring of two hybridmolecules of caffeine and eudistomin D were synthesized, and their affinity and selectivity for adenosinereceptors A1, A_<2A>, and A_3 were examined. One of the compounds showed the most potent affinity foradenosine receptor A_3 subtype.

  • Research Products

    (2 results)

All 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors Bioorg.2009

    • Author(s)
      Ishiyama, H.; Nakajima, H.; Nakata, H.; Kobayashi, J.
    • Journal Title

      Med. Chem. 17

      Pages: 4280-4284

    • Peer Reviewed
  • [Journal Article] Synthesis of eudistomin D analogues and its effects on adenosine receptors Bioorg.2008

    • Author(s)
      Ishiyama, H.; Ohshita, K.; Abe, T.; Nakata, H.; Kobayashi, J.
    • Journal Title

      Med. Chem. 16

      Pages: 3825-3830

    • Peer Reviewed

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi