2009 Fiscal Year Final Research Report
Synthesis of eudistomin D analogues and its effects on adenosine receptors
| Project/Area Number |
20790001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
ISHIYAMA Haruaki Hokkaido University, 大学院・薬学研究院, 助教 (70333622)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 生薬 / 天然物化学 |
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| Research Abstract |
Two analogues of eudistomin D, a β-carboline alkaloid from a marine tunicate Eudistoma olivaceum, were synthesized, and their affinity and selectivity for adenosine receptor subtypes A_1, A_<2A>, and A_<3> were examined. Both compounds exhibited the moderate affinity to the receptor A_3. On the other hand, four bis-N-n-propyl analogues in the uracil ring of two hybridmolecules of caffeine and eudistomin D were synthesized, and their affinity and selectivity for adenosinereceptors A1, A_<2A>, and A_3 were examined. One of the compounds showed the most potent affinity foradenosine receptor A_3 subtype.
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