2009 Fiscal Year Final Research Report
Development of Rh(I)-Catalyzed Hydroacylation Using a N-Heterocyclic Carbene as a Ligand
| Project/Area Number |
20790003
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
OONISHI Yoshihiro Hokkaido University, 大学院・薬学研究院, 助教 (70399955)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ロジウム / NHC / ヒドロアシル化 / アルデヒド / イオン液体 |
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| Research Abstract |
A Rh(I)-NHC catalyzed hydroacylation of 4-alkenals was investigated. As a result, it was found that the hydroacylation of 4-alkenals using a NHC as a ligands proceeded smoothly, giving cyclopentanone derivatives in high yields. And during the course of my investigation, it was also clear that the reaction of allenyl aldehydes, having an alkyne in the tether, with 10 mol% Rh(I)-NHC complexes at 65℃ produced a 5-8 fused bicyclic ketones in high yields. Furthermore, I succeeded in Rh(I)-catalyzed intramolecular hydroacylation of allenyl aldehydes.
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