2009 Fiscal Year Final Research Report
Development of new asymmetric phosphenium salt catalysts, and its application to the construction of chiral tetra-substituted carbon.
| Project/Area Number |
20790006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
HARADA Shinji Chiba University, 大学院・薬学研究院, 助教 (10451759)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 不斉触媒 / 有機合成化学 / 不斉四置換炭素 / ホスフェニウム / ウレア / イッテルビウム / Diels-Alder反応 |
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| Research Abstract |
Phosphorus compounds are known as Lewis basic chemicals, however, cationic phosphines have Lewis acidic character. I focused on phosphenium salts, and I found that they worked as a Lewis acidic catalyst for hetero-Diels-Alder reaction. Although I synthesized a variety of chiral phosphenium salts, catalytic asymmetric reactions were not realized. Meanwhile, I found that one bis-urea compound, which was a synthetic intermediate of chiral phosphenium salt, formed a good complex with Ytterbium to catalyze highly reactive and highly stereoselective Diels-Alder reaction.
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