2009 Fiscal Year Final Research Report
Synthetic studies on polycyclic alkaloids through carbamoyl metal complexes.
| Project/Area Number |
20790008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
YASUI Yoshizumi Tohoku University, 原子分子材料科学高等研究機構, 助教 (10432410)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 天然物合成 / 金属触媒反応 / アミド化 / アルカロイド / 不斉反応 |
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| Research Abstract |
Since polycyclic alkaloids are known to exhibit a broad range of important bioactivities, synthetic study of this class of compounds is an important task from pharmaceutical point of view. In this project, we studied a new method to approach polycyclic alkaloids by using carbamoyl metal complexes. As a result, lactam formation reaction starting from chloroformamides and cyanoformamides having olefin has been developed, and was applied to the syntheses of polycyclic alkaloids.
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