2009 Fiscal Year Final Research Report
Development of nulecytoplasmic shuttlepeptide and its applicatution for controlling distribution of disease related protein
| Project/Area Number |
20790012
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHIGENAGA Akira The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (10423394)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ペプチド / 有機合成化学 / 刺激応答 / ペプチド結合切断 / ケージド化合物 / シャトルペプチド |
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| Research Abstract |
Accumulation of a disease related mutated protein in a nucleus is observed in some intractable diseases. To treat these diseases, elimination of the mutated protein from nucleus is thought to be applicable. Therefore, we decided to develop a nucleocytoplasmic shuttle peptide, which beats inside a nucleus before exposure to a stimulus but it returns to a cytoplasm after exposure to a stimulus, with potential applicability to eliminate the mutated protein from a nucleus. As a results, we sucsessfully developed several stimulus-responsive amino acids which can be used for controlling a peptidyl function by a stimulus, and asymmetric synthesis of a key synthetic intermediate of the stimulus-responsive amino acids was achieved.
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[Journal Article] Praline cis/trans. isomerase Pinl regulates peroxisome proliferators-activated receptorγactivity through the direct binding to the AF-1 domain2010
Author(s)
Fujimoto, Y.; Shiraki, T.; Horiuchi, Y.; Waku, T.; Shigenaga, A.; Otaka, A.; ikura, T.; Igarashi, K.; Aimoto, S.; Tate, S.; Morikawa, K.
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Journal Title
J. Biol. Chem. 285
Pages: 3126-3132
Peer Reviewed
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[Presentation]2008
Organizer
若手化学者のための化学道場
Place of Presentation
徳島市
Year and Date
2008-09-11
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