2009 Fiscal Year Final Research Report
Development of the nucleoside analogs to harmonize with in vivo molecular function
| Project/Area Number |
20790013
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
TANIGUCHI Yosuke Kyushu University, 大学院・薬学研究院, 助教 (00452714)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 3本鎖DNA / W字型人工核酸 / アンチジーン / ミスマッチサイト |
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| Research Abstract |
In this study, we designed and synthesized the nucleoside analogs which interact with duplex DNA. Moreover, we aimed to establish the basic technology of the regulation of the gene expression using these nucleoside analogs. We have found that oligonucleotide containing the nucleoside analogs formed the stable triplex DNA as a result of interaction between the nucleoside analogs and duplex DNA. And this oligonucleotide inhibited the gene expression in the cultured cell.
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