2010 Fiscal Year Final Research Report
Synthetic study of euphorbias : antitumor and anti-HIV agents
| Project/Area Number |
20790016
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
WATANABE Kazuhiro Tohoku Pharmaceutical University, 薬学部, 講師 (10382673)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 抗腫瘍活性物質 / 抗HIV活性物質 / ユーフォルビア類 / 全合成 |
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| Research Abstract |
A new diterpenoid Euphorbia factor L_<11> was isolated from the seeds of Euphorbia lathyris by Yue and co-workers. The model compound of Euphorbia factor L_<11> was synthesized from cyclopentenone in 14 steps. The key cyclization includes a ring-closing metathesis (RCM) of triene with Grubbs's catalyst.
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[Journal Article] Total Synthesis of the Bicyclic Depsipept ide HDAC Inhibitors Spiruchostatins A and B, 5''-epi-Spiruchostatin B, FK228 (FR901228) and PreliminaryEvaluation of Their Biological Activity2009
Author(s)
Koichi Narita, Takuya Kikuchi, Kazuhiro Watanabe, Toshiya Takizawa, Takamasa Oguchi, Kyosuke Kudo, Keisuke Matsuhara, Hideki Abe, Takao Yamori, Minoru Yoshida, Tadashi Katoh
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Journal Title
Chem.Eur.J. 15
Pages: 11174-11186
Peer Reviewed
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