2009 Fiscal Year Final Research Report
Development of novel type of sequential glycosylation for creation of the synthetic vaccine.
| Project/Area Number |
20790017
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
SHIRAHATA Tatsuya Kitasato University, 薬学部, 講師 (30414056)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 合成化学 / 糖鎖合成 |
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| Research Abstract |
The novel type of one-pot sequential glycosylation with glycosyl carbamate and carbamothioate was achieved by changing the reaction temperature to utilize reactivity between those two glycosyl donors. This method could be applicatable to synthesize various trisaccharides such as glucose, galactose and mannose. Further application of synthetic vaccine are in progress in our laboratory.
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