2009 Fiscal Year Final Research Report
Development of efficient synthetic method for the natural product possessing sequential chiral quaternary carbons.
| Project/Area Number |
20790020
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
KAWAI Nobuyuki Kyoto Pharmaceutical University, 薬学部, 助教 (10411034)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 合成化学 |
|---|
| Research Abstract |
Synthesis of platencimycin and bicyclolactone unit of shimalacton possessing sequential quaternary carbons was investigated. In the former, the tri cyclic compound possessing the desired quaternary carbon was obtained with a high selectivity by heating the precursor which consists the diene unit possessing cyclopentane and the dienophile unit possessing tri-substituted alkene at 200℃. In the latter, by utilizing transannular cyclization of the lactone, the cyclopentane derivative was obtained as a sole product with the desired stereochemistry.
|
