2009 Fiscal Year Final Research Report
Search for lipid accumulation inhibitory and lipid metabolismpromoting constituents from medicinal foods
| Project/Area Number |
20790022
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
MORIKAWA Toshio Kinki University, 薬学総合研究所, 講師 (10340449)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 薬用食品 / 脂肪蓄積抑制作用 / 脂肪代謝促進作用 / メタボリックシンドローム / デイジーフラワー / Sapindus rarak / 垂盆草 / Piper chaba |
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| Research Abstract |
In order to investigate bioactive constituents from medicinal foods, we examined following extensive screening trials : (1) inhibitory effects on serum triglyceride (TG) elevation in olive oil-treated mice (2) TG accumulation inhibitory activity in HepG2 cells and TG metabolism-promoting activity in high glucose pretreated HepG2 cells, and (3) inhibitory effects on TNF-α-induced cytotoxicity in mouse primary cultured hepatocytes and/or L929 cells. As the results, (1) antihyperlipidemic saponin constituents were obtained from flowers of Bellis perennis and pericarps of Sapindus rarak, (2) lipid accumulation inhibitors were obtained from Sedum sarmentosum, and (3) TNF-α sensitivity degradation principles were obtained from Boesenbergia rotunda, Punica granatum, Helichrysum arenarium, and Piper chaba.
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[Journal Article] Medicinal flowers. XXVII. New flavanone and chalcone glycosides, arenariumosides I, II, III, and IV, and tumor necrosis factor-αinhibitors from everlasting, flowers of Helichrysum arenarium.2009
Author(s)
Morikawa T., Wang L. -B., Nakamura S., Ninomiya K., Yokoyama E., Matsuda H., Muraoka O., Wu L. -J., Yoshikawa M.
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Journal Title
Chem. Pharm. Bull. 57
Pages: 361-367
Peer Reviewed
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[Journal Article] Structures of acetylated oleanane-type triterpene saponins, rarasaponins IV, V, and VI, and anti-hyperlipidemic constituents from the pericarps of Sapindus rarak.2009
Author(s)
Asao Y., Morikawa T., Xie Y., Okamoto M., Hamao M., Matsuda H., Muraoka O., Yuan D., Yoshikawa M.
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Journal Title
Chem. Pharm. Bull. 57
Pages: 198-203
Peer Reviewed
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[Journal Article] Medicinal flowers. XXI. Structures of perennisaponins A, B, C, D, E, and F, acylated oleanane-type triterpene oligoglycosides, from the flowers of Bellis perennis.2008
Author(s)
Yoshikawa M., Li X., Nishida E., Nakamura S., Matsuda H., Muraoka O., Morikawa T.
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Journal Title
Chem. Pharm. Bull. 56
Pages: 559-568
Peer Reviewed
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[Presentation] タイ天然薬物ムクロジ(Sapindus rarak)果皮の血中中性脂質上昇抑制作用成分2008
Author(s)
森川敏生, 謝媛媛, 岡本将揮, 二宮清文, 村岡修, 松田久司, 浅尾恭伸, 濱尾 誠, 吉川雅之, 袁丹, Pongpiriyadacha Yutana
Organizer
日本生薬学会第55回年会
Place of Presentation
長崎
Year and Date
20080900
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