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2009 Fiscal Year Final Research Report

Development of efficient and sequential bond-forming reaction using diverse reactivity of conjugated imines

Research Project

  • PDF
Project/Area Number 20790023
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionKobe Pharmaceutical University

Principal Investigator

UEDA Masafumi  Kobe Pharmaceutical University, 薬学部, 講師 (00340935)

Project Period (FY) 2008 – 2009
Keywords合成化学 / ラジカル反応 / 共役イミン
Research Abstract

We are interested in the diverse reactivity of conjugated imines and successfully developed novel domino reactions involving regioselective radical addition reaction and subsequent hydroxylation with aerobic oxygen. Hydoxysulfenylation reaction via carbon-sulfur bond formation and hydroxylation and Hydoxyalkylation reaction via carbon-carbon bond formation and hydroxylation have been developed.

  • Research Products

    (9 results)

All 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Aerobic Hydroxylation of N-Borylenamine: Triethylborane-mediated Hydroxyalkylation of α, β-Unsaturated Oxime Ether.2009

    • Author(s)
      Ueda, M.; Miyabe, H.; Kimura, T.; Kondoh, E.; Naito, T.; Miyata, O.
    • Journal Title

      Org. Lett. 11

      Pages: 4632-4635

    • Peer Reviewed
  • [Journal Article] Two Novel Domino Reactions Triggered by Thiyl-Radical Addition to Vinylcyclopropyl Oxime Ether.2009

    • Author(s)
      Rahaman, H.; Ueda, M.; Miyata, O.; Naito, T.
    • Journal Title

      Org. Lett. 11

      Pages: 2651-2654

    • Peer Reviewed
  • [Journal Article] Carbon Radical Addition to N-Sulfonylimines Mediated by Triethylborane or Zinc.2009

    • Author(s)
      Ueda, M.; Miyabe, H.; Miyata, O.; Naito, T.
    • Journal Title

      Tetrahedron 65

      Pages: 1321-1326

    • Peer Reviewed
  • [Journal Article] Intermolecular Carbon Radical Addition to Cyclic Nitrone.2009

    • Author(s)
      Ueda, M.; Miyabe, H.; Nonoguchi, N.; Miyata, O.; Naito, T.
    • Journal Title

      Heterocycles 79

      Pages: 739-751

    • Peer Reviewed
  • [Journal Article] Regioselective Hydroxysulfenylation of α, β-Unsaturated Imines: Stability of Intermediate Radical Enhanced by Imino Group.2008

    • Author(s)
      Ueda, M.; Miyabe, H.; Shimizu, H.; Sugino, H.; Miyata, O.; Naito, T.
    • Journal Title

      Angew. Chem. Int. Ed. 47

      Pages: 5600-5604

    • Peer Reviewed
  • [Presentation] Hydroxyalkylation of α, β-Unsaturated oxime ether2009

    • Author(s)
      Ueda M., Naito T., Miyata O.
    • Organizer
      4th Pacific Symposium on Radical Chemistry
    • Place of Presentation
      Shanghai
    • Year and Date
      2009-11-20
  • [Presentation] 共役イミン類のヒドロキシスルフィド化およびヒドロキシアルキル化反応の開発2009

    • Author(s)
      上田昌史、清水秀憲、木村隆浩、近藤瑛子、内藤猛章、宮田興子
    • Organizer
      第35回反応と合成の進歩シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2009-11-17
  • [Presentation] アルキニルオキシムエーテル類への位置特異的共役付加反応の開発2008

    • Author(s)
      上田昌史、吉田勤一、池田祐紀、宮田興子、宮部豪人、内藤猛章
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-11-04
  • [Presentation] Domino Radical Reaction of α, β-Unsaturated Oxime Ether2008

    • Author(s)
      Ueda M., Miyabe H., Miyata O., Naito T.
    • Organizer
      The Fifth International Symposium on Integrated Synthesis
    • Place of Presentation
      Kobe
    • Year and Date
      2008-09-05

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Published: 2011-06-18   Modified: 2016-04-21  

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