2009 Fiscal Year Final Research Report
Synthesis of Chiral Spherical Aromatic Amides and Construction of Chiral Nano Space
| Project/Area Number |
20790024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
MASU Hyuma Tokushima Bunri University, 香川薬学部, 助教 (80412394)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 有機化学 / ナノ材料 / 結晶工学 / 不斉 / X線結晶解析 |
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| Research Abstract |
The aromatic amide tetramers as spherical molecules are constructed from four benzene rings connected by six amide bonds, and have multiple functionalizable points and asymmetric structures. The spherical molecules were obtained racemic mixtures. Enantiomers were separated by chiral HPLC and related to their CD spectra. In the racemic crystal of the spherical molecule 1, both enantiomeric molecules were arranged in a circle and formed a channel-shaped network structure by weak intermolecular interactions. The channel incorporated water molecules which form 1D chain cluster. Racemic crystal of 2 has also channel-shaped network structure. Otherwise, enantio-pure 2 did not form the channel-shaped structure in the crystal. In addition, complex of spherical molecule 1 or 2 with metal cation formed a different channel-shaped structure in the crystal.
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