2009 Fiscal Year Final Research Report
Development of a novel quantification method for simultaneous screeningof bioactive peptides.
| Project/Area Number |
20790028
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
GOTO Takaaki Tohoku University, 大学院・薬学研究科, 講師 (40344684)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 生理活性ペプチド / 多成分スクリーニング / 抗体 / 質量分析法 / MALDI / アンジオテンシン / 安定同位元素標識 |
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| Research Abstract |
A novel methodology to screen various target bioactive peptides has been examined. That is based on the group-specific immunoaffinity extraction followed by direct MALDI-TOF/MS analysis. This strategy can be used for any bioactive peptides as long as the antibodies are available. This could help for the efficient diagnostic/therapeutic marker discovery in a disease state.
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