2009 Fiscal Year Final Research Report
Development of precise re-examine system of newborn mass screening based on liquid chromatography-mass spectrometry (LC-MS)
| Project/Area Number |
20790031
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
NISHIO Tadashi Keio University, 薬学部, 助教 (80401892)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 臨床分析科学 / 新生児マススクリーニング / 先天性副腎過形成症 / 先天性甲状腺機能低下症 / LC-MS / 誘導体化 / 温度応答性クロマトグラフィー |
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| Research Abstract |
High-sensitive and reliable analytical methods are required for newborn mass screening. As for low-birth weight infants, high false positive rate of diseases are observed in the first screening assay. Based on this background, we developed the effective analytical methods of biomarker, utilizing the igh-performance liquid chromatography-mass spectrometry (LC-MS). Furthermore, we applied the temperature-responsive chromatography to quantification of anesthetic agents in biological fluids. In this chromatography system, only water is used as the mobile phase, and there are many advantages from the point of view of the green chemistry.
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