2009 Fiscal Year Final Research Report
Physical Chemistry of Lipid-Apolipoprotein Interaction in HDL Biogenesis
| Project/Area Number |
20790032
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
NAKANO Minoru Kyoto University, 薬学研究科, 准教授 (70314226)
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| Project Period (FY) |
2008 – 2009
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| Keywords | コレステロール / アポリポタンパク質 / ABCA1 / HDL / 両親媒性ペプチド |
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| Research Abstract |
We investigate apolipoprotein A-I-lipid membrane interaction to elucidate mechanism of the formation of HDLs, which act as anti-atherogenic. We found discoidal lipid-apolipoprotein complexes are spontaneously formed by the change in the lipid compositions and pH at membrane's surface. Structure and lipid dynamics of the discoidal complexes were also evaluated by means of neutron scattering and fluorescence analyses.
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