2009 Fiscal Year Final Research Report
AGE-RAGE interaction as a target for drug design against diabetes complications
| Project/Area Number |
20790034
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHIDA Takuya Osaka University, 薬学研究科, 助教 (00294116)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 構造生物学 |
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| Research Abstract |
We have analyzed the conformational dynamics of the variable-type domain of RAGE (Receptor for AGE), which has been revealed to contain the binding site of AGE. Based on the results of NMR and MD calculation, a combination of virtual and in vitro screening was carried out to find suitable chemical compounds to interfere with the AGE-RAGE binding. As a result, chemical compounds were identified as candidates for RAGE inhibitor.
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[Journal Article] Solution structure of the variable-type domain of the receptor for advanced glycation end products: new insight into AGE-RAGE interaction.2008
Author(s)
Matsumoto S, Yoshida T, Murata H, Harada S, Fujita N, Nakamura S, Yamamoto Y, Watanabe T, Yonekura H, Yamamoto H, Ohkubo T, Kobayashi Y.
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Journal Title
Biochemistry 47
Pages: 12299-311
Peer Reviewed
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