Influence of tumor lymphangiogenesis on tumor-targeting liposomal DDS

2010 Fiscal Year Final Research Report

• Project/Area Number: 20790041
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Physical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: SHIMIZU Kosuke University of Shizuoka, 薬学部・大学院・薬学研究科, 助教 (30423841)
• Project Period (FY): 2008 – 2010
• Keywords: ドラッグデリバリー

Research Abstract

It is known that the microenvironment surrounding tumor cells is continuously changed. Recent studies have demonstrated that lymphangiogenesis, an event involving construction of new lymphatic vessels, frequently occurs in tumor tissue and contributes to lymph node metastasis of tumors. Since lymphatic vessels in tissues function as a drainage system, tumor lymphangiogenesis would be considered to affect the liposomal accumulation in the tumor. In this study, we found that lymphangiogenesis caused the decrease in tumor accumulation of liposomes, and demonstrated the influence of tumor lymphangiogenesis on tumor-targeting liposomal DDS.

Research Products

• [Journal Article] Anti-angiogenic activity and intracellular distribution of epigallocatechin-3-gallate analogs. (2011)
  • Author(s): Piyaviriyakul S, Shimizu K, Asakawa T, Kan T, Siripong P, Oku N.
  • Journal Title: Biol Pharm Bull. 34 Pages: 396-400
  • Peer Reviewed
• [Journal Article] PET imaging of brain cancer with positron emitter-labeled liposomes. (2010)
  • Author(s): Oku N, Yamashita M, Katayama Y, Urakami T, Hatanaka K, Shimizu K, Asai T, Tsukada H, Akai S, Kanazawa H.
  • Journal Title: Int J Pharm. 403 Pages: 170-177
  • Peer Reviewed
• [Journal Article] Anti-obesity effect of phosphatidylinositol on diet-induced obesity in mice. (2010)
  • Author(s): Shimizu K, Ida T, Tsutsui H, Asai T, Otsubo K, Oku N.
  • Journal Title: J.Agric.Food Chem. 58 Pages: 11218-11225
  • Peer Reviewed
• [Journal Article] Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane. (2010)
  • Author(s): Shimizu K, Osada M, Takemoto K, Yamamoto Y, Asai T, Oku N.
  • Journal Title: J.Control.Release 141 Pages: 208-215
  • Peer Reviewed
• [Journal Article] Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice. (2010)
  • Author(s): Shimizu K, Kinouchi Shimizu N, Hakamata W, Unno K, Asai T, Oku N.
  • Journal Title: Biol.Pharm.Bull. 33 Pages: 117-121
  • Peer Reviewed
• [Journal Article] A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy. (2010)
  • Author(s): Murase Y, Asai T, Katanasaka Y, Sugiyama T, Shimizu K, Maeda N, Oku N.
  • Journal Title: Cancer Lett. 287 Pages: 165-171
  • Peer Reviewed
• [Journal Article] In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography. (2009)
  • Author(s): Urakami T, Kawaguchi AT, Akai S, Hatanaka K, Koide H, Shimizu K, Asai T, Fukumoto D, Harada N, Tsukada H, Oku N.
  • Journal Title: Artif.Organs 33 Pages: 164-168
  • Peer Reviewed
• [Journal Article] Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-in dol-2-one, SU5416. (2008)
  • Author(s): Katanasaka Y, Ida T, Asai T, Shimizu K, Koizumi F, Maeda N, Baba K, Oku N.
  • Journal Title: Cancer Lett. 270 Pages: 260-268
  • Peer Reviewed
• [Journal Article] Enhanced experimental tumor metastasis with age in senescence-accelerated mouse. (2008)
  • Author(s): Shimizu K, Kinouchi Shimizu N, Asai T, Tsukada H, Oku N.
  • Journal Title: Biol.Pharm.Bull. 31 Pages: 847-851
  • Peer Reviewed
• [Journal Article] Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC. (2008)
  • Author(s): Asai T, Miyazawa S, Maeda N, Hatanaka K, Katanasaka Y, Shimizu K, Shuto S, Oku N.
  • Journal Title: Cancer Sci. 99 Pages: 1029-1033
  • Peer Reviewed
• [Presentation] Liposomal tumor targeting and tumor lymphangiogenesis. (2010)
  • Author(s): Kosuke Shimizu, et al.
  • Organizer: LRD/LLMB 2010 Conference
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 20100804-20100807
• [Presentation] 腫瘍リンパ管新生が及ぼす薬物ナノキャリア腫瘍移行性への影響 (2010)
  • Author(s): 清水広介, ら
  • Organizer: 第74回日本生化学会中部支部例会・シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-05-29
• [Presentation] 腫瘍リンパ管新生がリポソームのがん集積性に与える影響 (2010)
  • Author(s): 清水広介, ら
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-12
• [Presentation] リポソーム腫瘍内挙動に対するリンパ管新生の影響 (2010)
  • Author(s): 山口里美, ら
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-29
• [Presentation] Involvement of lymphangiogenesis in tumor-targeting liposomal delivery. (2009)
  • Author(s): Satomi Yamaguchi, et al.
  • Organizer: 4th International Liposome Society Conference
  • Place of Presentation: London, UK
  • Year and Date: 2009-12-14
• [Presentation] リンパ管新生が及ぼすリポソームの腫瘍集積性への影響 (2009)
  • Author(s): 山口里美, ら
  • Organizer: 第25回日本DDS学会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-03
• [Presentation] リンパ管新生が及ぼすリポソームの腫瘍内挙動への影響 (2008)
  • Author(s): 山口里美, ら
  • Organizer: Biochemistry and Molecular Biology 2008
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Tumor-targeting liposomal DDS and lymphagiogenesis. (2008)
  • Author(s): Kosuke Shimizu, et al.
  • Organizer: 11th Liposome Research Days Conference
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2008-07-20
• [Presentation] リポソームの腫瘍受動標的化におけるリンパ管新生の影響 (2008)
  • Author(s): 清水広介, ら
  • Organizer: 第24回日本DDS学会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-30
• [Remarks] ホームページ等