2009 Fiscal Year Final Research Report
In vivo activated glia imaging by development of novel peripheral benzodiazepine receptor ligands
| Project/Area Number |
20790047
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
MAEDA Jun National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員 (30415426)
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| Project Period (FY) |
2008 – 2009
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| Keywords | イメージング |
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| Research Abstract |
To visualize the neuroinflammation of human brain by positron emission tomography (PET), I synthesized novel PBR positron-labeled ligand [^<11>C]AC-5216 and its derivatives, and invested the profiles of these ligands. [^<11>C]AC-5216 is useful ligand for imaging of neuroinflammation in rodent brain. Since [^<11>C]AC-5216 had a lot of individual variation about brain uptake in human PET study, improvement of chemical structure was necessary for imaging of human neuroinflammation.
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[Journal Article] Development of N-[11C]methylamino 4-hydroxy-2(1H)-quinolone derivatives as PET radioligands for the glycine-binding site of NMDA receptors.2009
Author(s)
Fuchigami T, Haradahira T, Fujimoto N, Nojiri Y, Mukai T, Yamamoto F, Okauchi T, Maeda J, Suzuki K, Suhara T, Yamaguchi H, Ogawa M, Magata Y, Maeda M.
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Journal Title
Bioorg Med Chem 17(15)
Pages: 5665-5675
Peer Reviewed
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[Journal Article] Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with [11C]-AC-5216.2009
Author(s)
Miyoshi M, Ito H, Arakawa R, Takahashi H, Takano H, Higuchi M, Okumura M, Otsuka T, Kodaka F, Sekine M, Sasaki T, Fujie S, Seki C, Maeda J, Nakao R, Zhang MR, Fukumura T, Matsumoto M, Suhara T.
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Journal Title
J Nucl Med 50(7)
Pages: 1095-1101
Peer Reviewed
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[Journal Article] Utility of small-animal positron emission tomographic imaging of rats for preclinical development of drugs acting on the serotonin transporter2009
Author(s)
Saijo T, Maeda J, Okauchi T, Maeda JI, Morio Y, Kuwahara Y, Suzuki M, Goto N, Suzuki K, Higuchi M, Suhara T.
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Journal Title
Int J Neuropsychopharmacol 23
Pages: 1-12
Peer Reviewed
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[Journal Article] Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system2009
Author(s)
Tokunaga M, Seneca N, Shin RM, Maeda J, Obayashi S, Okauchi T, Nagai Y, Zhang MR, Nakao R, Ito H, Innis RB, Halldin C, Suzuki K, Higuchi M, Suhara T.
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Journal Title
J Neurosci 29(6)
Pages: 1887-1896
Peer Reviewed
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[Journal Article] Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies2008
Author(s)
Ji B, Maeda J, Sawada M, Ono M, Okauchi T, Inaji M, Zhang MR, Suzuki K, Ando K, Staufenbiel M, Trojanowski JQ, Lee VM, Higuchi M, Suhara T.
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Journal Title
J Neurosci 28(47)
Pages: 12255-12267
Peer Reviewed
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[Journal Article] Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders2008
Author(s)
Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T.
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Journal Title
Peer Reviewed
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[Journal Article] Difference in brain distributions of carbon 11-labeled 4-hydroxy-2(1H)-quinolones as PET radioligands for the glycine-binding site of the NMDA ion channel2008
Author(s)
Fuchigami T, Haradahira T, Fujimoto N, Okauchi T, Maeda J, Suzuki K, Suhara T, Yamamoto F, Sasaki S, Mukai T, Yamaguchi H, Ogawa M, Magata Y, Maeda M.
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Journal Title
Nucl Med Biol 35(2)
Pages: 203-212
Peer Reviewed
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