2009 Fiscal Year Final Research Report
STAP-2 modulates activation-induced cell death in T-cell
| Project/Area Number |
20790050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
SEKINE Yuichi Hokkaido University, 大学院・薬学研究院, 助教 (20396295)
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| Project Period (FY) |
2008 – 2009
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| Keywords | T細胞 / アポトーシス / AICD(活性化誘導性細胞死) / アダプター分子 / STAP-2 / 自己免疫疾患 / Caspase / シグナル伝達 |
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| Research Abstract |
Adaptor protein STAP-2 is a multifunctional molecule which regulates cellular signaling negatively or positively in immune responses. In this study, I investigated the functional mechanisms of STAP-2 in T-cell activation-induced cell death(AICD). It is revealed that STAP-2 enhances T-cell apoptosis, so STAP-2 plays a role in T-cell AICD.
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