2009 Fiscal Year Final Research Report
Analysis of DAXX-mediated cell death in pro-B cell line
| Project/Area Number |
20790051
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
MUROMOTO Ryuta Hokkaido University, 大学院・薬学研究院, 助教 (30455597)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | インターフェロン / DAXX / アポトーシス / STAT3 / 免疫学 / 分子生物学 / サイトカイン / TYK2 |
|---|
| Research Abstract |
Interferon-α and-β inhibit the interleukin-7-mediated growth and survival of T and B lymphoid progenitors. DAXX expression has been reported to be essential for the inhibitory effect of type I interferons, although the mechanisms involved remain unclear. Here, we examined the role of DAXX in the gp130/STAT3-dependent cell growth/survival signals. We found that DAXX suppresses gp130-mediated cell growth and survival thorough the transcriptional repression of genes.
|
