2009 Fiscal Year Final Research Report
Clarification of novel physiological roles of ERK5 in neurons
| Project/Area Number |
20790053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
OBARA Yutaro Tohoku University, 大学院・薬学研究科, 助教 (40400270)
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| Project Period (FY) |
2008 – 2009
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| Keywords | シグナル伝達 / 神経科学 / 痴呆 / 脳・神経 / 薬理学 |
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| Research Abstract |
The purpose of this study is to clarify the involvements of ERK5 in differentiation of PC12 cells, a model cell line of immature neurons. By inhibiting ERK5-dependent signaling, neurite outgrowth by NGF was significantly blocked and expression level of tyrosine hydroxylase, a neurotransmitter synthesizing enzyme, was largely reduced. Furthermore, 57 ERK5-selective genes that were up-regulated during the differentiation were identified. These results suggest ERK5 causes neuronal differentiation accompanied by various gene expression.
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