2009 Fiscal Year Final Research Report
The nuclear function of nonreceptor tyrosine kinases.
| Project/Area Number |
20790055
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
FUKUMOTO Yasunori Chiba University, 大学院・薬学研究院, 助教 (10447310)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 非受容体型チロシンキナーゼ / タンパク質チロシンリン酸化 / DNA損傷応答 / 細胞周期 / 細胞核機能 / 細胞核構造 / 発がん |
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| Research Abstract |
Nonreceptor tyrosine kinases (NRTKs) work under plasma membrane in combination with transmembrane receptors, but recent reports showed that these NRTKs can translocate to the nucleus. We found that NRTKs regulate DNA damage checkpoint, chromatin condensation associated by apoptosis and nuclear structure through nuclear protein tyrosine phosphorylation, and analyzed the molecular mechanisms. These results give novel insights into the use of molecular-targeting anti-cancer drugs and the improvement of chemotherapy and radiation therapy.
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[Journal Article] Costeffective gene transfection by DNA compaction at pH 4. 0 using acidified, long shelf-life polyethylenimine.2010
Author(s)
Fukumoto Y, Obata Y, Ishibashi K, Tamura N, Kikuchi I, Aoyama K, Hattori Y, Tsuda K, Nakayama Y, Yamaguchi N
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Journal Title
Cytotechnol. 62
Pages: 73-82
Peer Reviewed
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[Journal Article] Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain.2009
Author(s)
Sato I, Obata Y, Kasahara K, Nakayama Y, Fukumoto Y, Yamasaki T, Yokoyama KK, Saito T, Yamaguchi N
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Journal Title
J. Cell Sci. 122
Pages: 965-975
Peer Reviewed
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[Journal Article] Nuclear localization of magphinins, alternative splicing products of the human trophinin gene.2008
Author(s)
Aoyama J, Akazawa Y, Kasahara K, Higashiyama Y, Kikuchi I, Fukumoto Y, Saburi S, Nakayama Y, Fukuda MN, Yamaguchi N
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Journal Title
J. Cell. Biochem. 103
Pages: 765-777
Peer Reviewed
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