Regulatory mechanisms of cell survival by glutamine transporter in the brain

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790061
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: NAKAMICHI Noritaka Kanazawa University, 薬学系, 准教授 (10401895)
• Project Period (FY): 2008 – 2009
• Keywords: 脳・神経 / 脳神経疾患 / 神経科学 / 薬理学 / 輸送担体

Research Abstract

To elucidate physiological and pathological role of glutamine transporters (GlnTs) expressed on astrocytes, we examined affects of GlnTs on the resistibility to the oxidative stress in astrocytes or the vulnerability to the neurotoxicity. As a result, it was suggested that GlnTs may be functionally expressed on astrocytes to increase the sensitivity to the oxidative stress in astrocytes or to protect neurons from the neurotoxicity through the release of neurotrophic factors.

Research Products

• [Journal Article] Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. (2010)
  • Author(s): Fukumori, R., Nakamichi, N., Takarada, T., Kambe, Y., Matsushima, N., Moriguchi, N., Yoneda, Y.
  • Journal Title: J. Pharmacol. Sci. 112(3) Pages: 273-281
  • Peer Reviewed
• [Journal Article] A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus. (2009)
  • Author(s): Takarada, T., Tamaki, K., Takumi, T., Ogura, M., Ito, Y., Nakamichi, N., Yoneda, Y.
  • Journal Title: J. Neurochem. 110(5) Pages: 1457-1468
  • Peer Reviewed
• [Journal Article] Possible promotion of neuronal differentiation in fetal rat brain neural progenitor cells after sustained exposure to static magnetism. (2009)
  • Author(s): Nakamichi, N., Ishioka, Y., Hirai, T., Ozawa, S., Tachibana, M., Nakamura, N., Takarada, T., Yoneda, Y.
  • Journal Title: J. Neurosci. Res. 87(11) Pages: 2406-2417
  • Peer Reviewed
• [Journal Article] Possible protection by notoginsenoside R1 against neurotoxicity of N-methyl-D-aspartate receptor composed of an NR1/NR2B heteromeric assembly. (2009)
  • Author(s): Gu, B., Nakamichi, N., Zhang, W.S., Nakamura, Y., Kambe, Y., Fukumori, R., Takuma, K., Yamada, K., Takarada, T., Taniura, H., Yoneda, Y.
  • Journal Title: J. Neurosci. Res. 87(9) Pages: 2145-2156
  • Peer Reviewed
• [Journal Article] Neurogenesis mediated by GABA and glutamate signaling. (2009)
  • Author(s): Nakamichi, N., Takarada, T., Yoneda, Y.
  • Journal Title: J. Pharmacol. Sci. 110(2) Pages: 133-149
  • Peer Reviewed
• [Journal Article] Group III metabotropic glutamate receptor activation suppresses self-replication of undifferentiated neocortical progenitor cells. (2008)
  • Author(s): Nakamichi, N., Yoshida, K., Ishioka, Y., Makanga, J.O., Fukui, M., Yoneyama, M., Kitayama, T.
  • Journal Title: J. Neurochem. 105(5) Pages: 1996-2012
  • Peer Reviewed
• [Journal Article] Yoneda, Y.: Upregulation of ciliary neurotrophic factor expression by GABAA receptors in undifferentiated neural progenitors of fetal mouse brain. (2008)
  • Author(s): Fukui, M., Nakamichi, N., Yoneyama, M., Yoshida, K., Ozawa, S., Kitayama, T., Nakamura, N., Taniura, H.
  • Journal Title: J. Neurosci. Res. 86(12) Pages: 2615-2623
  • Peer Reviewed
• [Journal Article] Insensitivity to glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors in association with delayed mitochondrial membrane potential disruption in cultured rat cortical neurons. (2008)
  • Author(s): Kambe, Y., Nakamichi, N., Georgiev, D.D., Nakamura, N., Taniura, H., Yoneda, Y.
  • Journal Title: J. Neurochem. 105(5) Pages: 1886-1900
  • Peer Reviewed
• [Journal Article] Promotion of neuronal differentiation through activation of NMDA receptors transiently expressed by undifferentiated neural progenitor cells in fetal rat neocortex. (2008)
  • Author(s): Yoneyama, M., Nakamichi, N., Fukui, M., Kitayama, T., Georgiev, D.D., Makanga, J.O., Nakamura, N., Taniura, H., Yoneda, Y.
  • Journal Title: J. Neurosci. Res 86(11) Pages: 2392-2402
  • Peer Reviewed
• [Journal Article] Modulation of cellular proliferation and differentiation through GABAB receptors expressed by undifferentiated neural progenitor cells isolated from fetal mouse brain. (2008)
  • Author(s): Fukui, M., Nakamichi, N., Yoneyama, M., Ozawa, S., Fujimori, S., Takahata, Y., Nakamura, N., Taniura, H., Yoneda, Y.
  • Journal Title: J. Cell. Physiol. 216(2) Pages: 507-519
  • Peer Reviewed
• [Presentation] グリア細胞におけるグルタミントランスポーターの細胞内局在 (2010)
  • Author(s): 佐古彩, 小椋正人, 中道範隆, 宝田剛志, 米田幸雄
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 20100316-20100318
• [Presentation] マウスにおけるカルニチン/有機カチオントランスポーターの機能的発現 (2010)
  • Author(s): 中道範隆, 杉浦智子, 田口貴之, 清水 卓也, 若山友彦, 井関尚一, 辻彰, 加藤将夫
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 20100316-20100318
• [Presentation] Functional expression of carnitine/organic cation transporter OCTN1 (SLC22A4) in mouse small intestine. (2009)
  • Author(s): Shimizu, T., Sugiura, T., Nakamichi, N., Wakayama, T., Iseki, S., Kubo, Y., Tamai, I., Tsuji, A., Kato, Y.
  • Organizer: 日本薬物動態学会第24回年会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 20091127-20101129
• [Presentation] Suppression by myosion VI of neural progenitor proliferation. (2009)
  • Author(s): Nakamichi, N., Yoneda, Y.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
  • Year and Date: 20090823-20090828
• [Presentation] Glutamine transporter expressed by glial cells in glutamate neurotoxicity. (2009)
  • Author(s): Iemata, M., Ogura, M., Taniura, H., Nakamichi, N., Takarada, T., Yoneda, Y.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
  • Year and Date: 20090823-20090828
• [Presentation] アストログリア細胞に発現するグルタミントランスポーターによるグルタミン酸神経毒性防御 (2009)
  • Author(s): 家亦美佳, 小椋正人, 谷浦秀夫, 中道 範隆, 宝田剛志, 米田幸雄
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 会, 伊香保温泉ホテル天坊(群馬)
  • Year and Date: 20090621-20090624
• [Presentation] グリア細胞に発現するグルタミントランスポーターのグルタミン酸神経毒性における役割 (2009)
  • Author(s): 小椋正人, 谷浦秀夫, 中道範隆, 米田 幸雄
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 20090316-20090318
• [Presentation] ラットアストログリア細胞に発現するグルタミントランスポーターは酸化的ストレス感受性を調節する (2008)
  • Author(s): 小椋正人, 福森良, 伊東佑真, 中道範隆, 谷浦秀夫, 米田幸雄
  • Organizer: 第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 品川プリンスホテル(東京)
  • Year and Date: 20081001-20081003
• [Presentation] アストログリア細胞に発現するグルタミントランスポーターは酸化的ストレス脆弱性決定因子である (2008)
  • Author(s): 小椋正人, 福森良, 伊東佑真, 中道範隆, 谷浦秀夫, 米田幸雄
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山国際会議場(富山)
  • Year and Date: 20080911-20080913
• [Presentation] グルタミントランスポーターによる酸化的ストレス感受性の決定機構 (2008)
  • Author(s): 小椋正人, 谷浦秀夫, 中道範隆, 米田 幸雄
  • Organizer: 第114回日本薬理学会近畿部会
  • Place of Presentation: 神戸商工会議所(神戸)
  • Year and Date: 2008-11-14
• [Book] Glutamatergic signaling in neurogenesis.(Maiese K., ed., Neurovascular Medicine) (2009)
  • Author(s): Nakamichi, N., Yoneda, Y.
  • Total Pages: 269-288
  • Publisher: Oxford University Press