2009 Fiscal Year Final Research Report
Elucidation of regulatory mechanism of B cell activation by the change in sialic acid species
| Project/Area Number |
20790063
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
NAITO Yuko Kyoto University, 生命科学研究科, 助教 (10456775)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | シアル酸 / B細胞 / 胚中心 |
|---|
| Research Abstract |
I have reported that major sialic acid species is dramatically changed in activated B cells in germinal centers, the formation of which is triggered by immunization with thymus-dependent (TD) antigen. In this project, I established genetically modified mice that were expected to cancel the activation-dependent change in sialic acid species, and analyzed B cell phenotypes of these mice. Since these mice formed germinal centers upon TD antigen immunization, I examined antibody production in TD response.
|
