2009 Fiscal Year Final Research Report
Molecular mechanism regulating the localization of Reelin and its functional Receptors.
| Project/Area Number |
20790069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
BABA Atsushi Nagoya City University, 大学院・薬学研究科, 助教 (70405215)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 脳・神経 / 発生・分化 / 分泌蛋白質 |
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| Research Abstract |
Reelin is a secreted protein essential for brain development. We analyzed when and where Reelin acts in developing forbrain. Functional Receptors are mainly present at newborn neurons, and they are downregulated at postmigrating neurons. We further identified some kinds of glycoproteins as candidate binding factor of Reelin at the extracellular milieu. These results suggest that Reelin protein is not merely a diffusive molecule, but also is affected by extracellular matrices or by acceptor cells.
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