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2009 Fiscal Year Final Research Report

Functional analyses of fad104 on survival just after birth and insulin sensitivity.

Research Project

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Project/Area Number 20790070
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionNagoya City University

Principal Investigator

NISHIZUKA Makoto  Nagoya City University, 大学院・薬学研究科, 講師 (00363953)

Project Period (FY) 2008 – 2009
Keywords肥満 / 糖尿病 / 脂肪細胞分化 / 新生児疾患 / 遺伝子発現 / 肺形成
Research Abstract

In this study, we demonstrated that fad104, a positive regulator of adipogenesis, has a crucial role for regulating the formation of white adipose tissue and insulin sensitivity. Furthermore, we also demonstrated that fad104 is essential for lung development just after birth.

  • Research Products

    (15 results)

All 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (10 results)

  • [Journal Article] Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation.2010

    • Author(s)
      Kishimoto K., Kato A., Osada S., Nishizuka M., Imagawa M.
    • Journal Title

      Biochem. Biophys. Res. Commun. (in press)

    • Peer Reviewed
  • [Journal Article] The role of C/EBPdelta in the early stages of adipogenesis.2009

    • Author(s)
      Hishida T., Nishizuka M., Osada S., Imagawa M
    • Journal Title

      Biochimie 91(5)

      Pages: 654-657

    • Peer Reviewed
  • [Journal Article] Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion2009

    • Author(s)
      Nishizuka M., Kishimoto K., Kato A., Ikawa, M., Okabe, M., Sato R., Niida H., Nakanishi M., Osada S., Imagawa M.
    • Journal Title

      spreading and migration Exp. Cell Res. 315(5)

      Pages: 809-819

    • Peer Reviewed
  • [Journal Article] A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion.2008

    • Author(s)
      Hishida T., Eguchi T., Osada S., Nishizuka M., Imagawa M.
    • Journal Title

      FEBS J. 275(22)

      Pages: 5576-5588

    • Peer Reviewed
  • [Journal Article] Wnt4 and Wnt5a promote adipocyte differentiation.2008

    • Author(s)
      Nishizuka M., Koyanagi A., Osada S., Imagawa M.
    • Journal Title

      FEBS Lett. 582(21-22)

      Pages: 3201-3205

    • Peer Reviewed
  • [Presentation] 肺形成におけるfad104の機能解析2010

    • Author(s)
      岸本圭史、西塚誠、長田茂宏、今川正良
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
  • [Presentation] 脂肪細胞分化に重要であるfad104の肺発生における役割2009

    • Author(s)
      岸本圭史、西塚誠、長田茂宏、今川正良
    • Organizer
      第8回次世代を担う若手ファーマ・バイオフォーラム2009
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-14
  • [Presentation] 脂肪細胞分化に重要なfad104は出生直後の生命維持に必須である2009

    • Author(s)
      岸本圭史、西塚誠、加藤愛友美、長田茂宏、今川正良
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
  • [Presentation] Masayoshi Imagawa Heterozygous knockout of fad104 gene reduces body weight gain and increase glucose metabolism2009

    • Author(s)
      Makoto Nishizuka, Junko Kako, Keishi Kishimoto, Shigehiro Osada
    • Organizer
      21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      上海
    • Year and Date
      2009-08-05
  • [Presentation] Masayoshi Imagawa The novel gene fad104 is indispensable for lung development and is crucial role for cell proliferation, adhesion, migration and cytoskeletal organization.2009

    • Author(s)
      Keishi Kishimoto, Makoto Nishizuka, Ayumi Kato, Shigehiro Osada
    • Organizer
      21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      上海
    • Year and Date
      2009-08-05
  • [Presentation] fad104ヘテロ欠損は体重増加ならびにインスリン抵抗性を抑制する2009

    • Author(s)
      西塚誠、加子順子、岸本圭史、長田茂宏、今川正良
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
  • [Presentation] 脂肪細胞分化および出生直後の生命機能維持に必須であるfad104の機能解析2009

    • Author(s)
      岸本圭史、西塚誠、長田茂宏、今川正良
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
  • [Presentation] 脂肪細胞分化を促進するfad104が糖代謝能ならびにインスリン感受性に与える影響の解析2008

    • Author(s)
      西塚誠、加子順子、岸本圭史、長田茂宏、今川正良
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
  • [Presentation] 脂肪細胞分化に重要であるfad104欠損MEF (mouse embryo fibroblasts)の性状解析2008

    • Author(s)
      岸本圭史、西塚誠、長田茂宏、今川正良
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
  • [Presentation] 良新規遺伝子fad104欠損MEF (mouse embryo fibroblasts)の性状解析2008

    • Author(s)
      岸本圭史、西塚誠、長田茂宏、今川正
    • Organizer
      ファーマバイオフォーラム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-11-30

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Published: 2011-06-18   Modified: 2016-04-21  

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