2009 Fiscal Year Final Research Report
Novel mechanism for regulation of inflammatory response.
| Project/Area Number |
20790074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Takasaki University of Health and Welfare |
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Principal Investigator |
ITOU Masaaki Takasaki University of Health and Welfare, 薬学部, 助教 (30438759)
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| Research Collaborator |
MATSUOKA Isao 高崎健康福祉大学, 薬学部, 教授 (10145633)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 細胞外ヌクレオチド / プリン受容体 / マクロファージ / プロスタグランジン / 細胞内情報伝達 / 炎症反応 |
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| Research Abstract |
We have shown a new inhibitory mechanism against inflammatory response to extracellular nucleotides-induced Gq protein/phospholipase C (PLC) pathway. Because the Gq/PLC pathway consolidates several signal transductions caused by hormones and neurotransmitters, inhibition of this pathway may be an attractive target for novel therapeutic drugs.
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[Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.2010
Author(s)
Kimura T, Tomura H, Sato K, Masaaki Ito, Isao Matsuoka, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F.
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Journal Title
he Journal of Biological Chemistry Vol.285
Pages: 4387-4397
Peer Reviewed
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