2009 Fiscal Year Final Research Report
Studies on a novel bioactive phospholipid (s) that is produced by proinflammatory stimuli.
| Project/Area Number |
20790077
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
KUWATA Hiroshi Showa University, 薬学部, 助教 (80286864)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 生理活性脂質 / ケモカイン / ホスホリパーゼA2 |
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| Research Abstract |
This research found that 1) there are several types of PLX (PI/PE-form in addition to PC-form), 2) long chain acyl-CoA synthetase 4 (Acsl4) may be involved in the biosynthesis of PLX, 3) certain platelet-activating factor receptor antagonist inhibits PLX-mediated gene expression, 4) the induction of sPLA2-IIA expression is regulated by PKC isozymes.
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