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2009 Fiscal Year Final Research Report

functional analyses of the intracellular phospholipase A1 family in testes

Research Project

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Project/Area Number 20790078
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

ARIMITSU Nagisa  Tokyo University of Pharmacy and Life Science, 生命科学部, 助教 (40408688)

Project Period (FY) 2008 – 2009
Keywords発生生物学 / 遺伝子欠損マウス
Research Abstract

Phospholipases of the A1 (PLA1) cleave the sn-1 fatty acyl group from diacyl glycero-phospholipids and produce a free fatty acid and an sn-2-lysophospholipid. The intracellular phospholipase A1 (named iPLA1 from 2009 ) family consists of three members,α,β,γ. To reveal the physiological functions of iPLA1 family member, iPLA1 -β,-γknockout mice(KO)were generated by gene targeting. iPLA1-β and -γKO mice were born and were apparently indistinguishable from wild-type mice. However, male iPLA1-β KO mice were subfertile.

  • Research Products

    (2 results)

All 2009 2008

All Presentation (2 results)

  • [Presentation] PA-PAL1/iPAL1αの精子形成過程における発現時期の同定馬場有光なぎさ2009

    • Author(s)
      多賀谷光男、谷佳津子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイラ
    • Year and Date
      2009-10-22
  • [Presentation] 細胞内型ホスホリパーゼa1ファミリータンパク質の機能解析2008

    • Author(s)
      佐藤精一、木榑猛、有光なぎさ、森川麗、青木淳賢、新井洋由、多賀谷光男、谷佳津子
    • Organizer
      第81回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11

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Published: 2011-06-18   Modified: 2016-04-21  

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