2009 Fiscal Year Final Research Report
functional analyses of the intracellular phospholipase A1 family in testes
| Project/Area Number |
20790078
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Tokyo University of Pharmacy and Life Science |
|---|
Principal Investigator |
ARIMITSU Nagisa Tokyo University of Pharmacy and Life Science, 生命科学部, 助教 (40408688)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 発生生物学 / 遺伝子欠損マウス |
|---|
| Research Abstract |
Phospholipases of the A1 (PLA1) cleave the sn-1 fatty acyl group from diacyl glycero-phospholipids and produce a free fatty acid and an sn-2-lysophospholipid. The intracellular phospholipase A1 (named iPLA1 from 2009 ) family consists of three members,α,β,γ. To reveal the physiological functions of iPLA1 family member, iPLA1 -β,-γknockout mice(KO)were generated by gene targeting. iPLA1-β and -γKO mice were born and were apparently indistinguishable from wild-type mice. However, male iPLA1-β KO mice were subfertile.
|
