2009 Fiscal Year Final Research Report
Analysis of the synaptic basis underlying motor learning by mouse eyeblink conditioning
| Project/Area Number |
20790084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
KISHIMOTO Yasushi Tokushima Bunri University, 香川薬学部, 助教 (90441592)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 瞬目反射条件付け / 運動学習 / 内在性カンナビノイド / 代謝型グルタミン酸受容体 / Tetシステム |
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| Research Abstract |
To elucidate the molecular basis of motor learning, three paradigms of eyeblink conditioning (delay, trace and latent inhibition) were investigated by pharmacological treatment and/or genetically-engineered mice. In delay conditioning, endcannnabinoids 2-AG and anandamide are important for memory formation of eyeblink conditioning. Furthermore, this research clearly shown that multiple distinct molecular mechanisms exist for the expression and acquisition during eyeblink conditioning.
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