2009 Fiscal Year Final Research Report
The role of kinases on multiple G proteins activation by endothelin A receptor
| Project/Area Number |
20790086
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Matsuyama University |
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Principal Investigator |
HATAE Noriyuki Matsuyama University, 薬学部, 准教授 (30449912)
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| Project Period (FY) |
2008 – 2009
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| Keywords | プロテインキナーゼC / エンドセリンA受容体 / プロスタグランジン受容体 / G蛋白質 / 細胞内情報伝達 / 脂質ラフト |
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| Research Abstract |
G protein coupled receptors, like as endothelin A receptor, are the transmembrane spanning receptors, and the most commonly targeted receptor class for medicinal therapeutics. Agonist binding to the receptor causes them to adopt a conformation that results in the activations of associated multiple heterotrimeric G proteins, but it is still unknown how to selective activated the various G proteins by single receptor. It was clarified the role of protein kinases and lipid rafts on the selective activation of multiple G proteins mediated by receptor.
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[Journal Article] Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca^<2+> pathway in a lipid raft-dependent manner.2009
Author(s)
Yamaoka, K., Yano, A., Kuroiwa, K., Morimoto, K., Inazumi, T., Hatae, N., Tabata, H., Segi-Nishida, E., Tanaka, S., Ichikawa, A., Sugimoto, Y.
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Journal Title
Biochem. Biophys. Res. Commun. 389(4)
Pages: 678-682
Peer Reviewed
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