2009 Fiscal Year Final Research Report
Elucidation of physiological role of Laeverin, a novel aminopeptidase.
| Project/Area Number |
20790088
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kansai Medical University |
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Principal Investigator |
MARUYAMA Masato Kansai Medical University, 医学部, 助教 (00399445)
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| Project Period (FY) |
2008 – 2009
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| Keywords | Laeverin / 絨毛外栄養膜細胞 / エキソペプチダーゼモチーフ |
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| Research Abstract |
Here, we evaluated the roles of His^<379>, comprising the exopeptidase motif, in the enzymatic properties of human Laeverin. Our results indicate that His^<379> plays essential roles in its distinctive enzymatic properties and contributes to maintaining the appropriate structure of the catalytic cavity of the enzyme.
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[Presentation] Histidine-379 of human laeverin/aminopeptidase Q, a non-conserved residue within the exopeptidase motif, defines its distinctive enzymatic properties2009
Author(s)
Hattori A, Maruyama M, Arisaka N, Goto Y, Osawa Y, Inoue H, Fujiwara H, Tsujimoto M
Organizer
6th General Meeting of the International Proteolysis Society
Place of Presentation
Surfers Paradise, Australia
Year and Date
20091000
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