2009 Fiscal Year Final Research Report
Permeablity change of the nuclear envelope after mitosis.
| Project/Area Number |
20790090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHIMOZONO Satoshi The Institute of Physical and Chemical Research, 細胞機能探索技術開発チーム, 研究員 (40391982)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 核膜 / 蛍光タンパク質 / フォトコンバージョン |
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| Research Abstract |
Permeability of the nuclear envelope (NE) was investigated using a photoconvertible fluorescent protein, KikGR. It is widely believed that the barrier of the NE against the macromolecule diffusion is established at the end of mitosis and it does not change along the cell cycle. But, in this study, it was revealed that the barrier is loose at least during the first 30 minutes after cytokinesis. Furthermore, during the first 10 minutes, molecules with a molecular mass of as large as 210k can pass through the NE.
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