2009 Fiscal Year Final Research Report
The function and regulation of ABCA1 in neuron
| Project/Area Number |
20790091
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
OKUHIRA Keiichiro National Institute of Health Sciences, 機能生化学部, 主任研究官 (10425671)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 脂質 / 神経 |
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| Research Abstract |
In this study, we investigated the role of ATP binding cassette transporter A1 (ABCA1) in the neuronal growth and collapse of mouse neuroblastoma or primary rat neuron. In rat dorsal root ganglion (DRG) neurons, there was no clear difference in the neuronal growth between control and ABCA1-silencing cells. However, the repair of the damaged neuron was retarded by suppressing the ABCA1 expression, indicating that ABCA1 may function for the restoration of neuron.
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[Journal Article] SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.2008
Author(s)
Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML.
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Journal Title
Biochemistry 47(23)
Pages: 6138-47
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[Journal Article] The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines.2008
Author(s)
Nishimaki-Mogami T, Tamehiro N, Sato Y, Okuhira K, Sai K, Kagechika H, Shudo K, Abe-Dohmae S, Yokoyama S, Ohno Y, Inoue K, Sawada J.
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Journal Title
Biochem Pharmacol 76(8)
Pages: 1006-13
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