2009 Fiscal Year Final Research Report
Analysis of translational inhibition by basic amino acid repeat
| Project/Area Number |
20790095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AKIMITSU Nobuyoshi The University of Tokyo, アイソトープ総合センター, 准教授 (40294962)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 翻訳 / 遺伝子 / ゲノム |
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| Research Abstract |
Bio-infomatic analysis revealed that human genome encode 267 genes which harbor basic amino acid repast. This suggests that 0.7% of all human genes are regulated by basic amino acid repast-mediated translational repression. To investigate this idea, several reporter genes encoding basic amino acid repast sequence were constructed and tested. Moreover, we found that TAT gene encoded in HIV genome also encodes basic amino acid repast. However, basic amino acid repast of TAT gene is not involved in translational repression-mediated gene regulation.
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