2009 Fiscal Year Final Research Report
Creation of drug candidates for the treatment of inflammatory orphan disease
| Project/Area Number |
20790101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Okayama University |
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Principal Investigator |
KAKUTA Hiroki Okayama University, 大学院・医歯薬学総合研究科, 准教授 (80362961)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 医薬分子設計 / 希少疾病 / 潰瘍性大腸炎 / クローン病 / レチノイドX受容体 / レチノイン酸受容体 / in vivo評価 |
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| Research Abstract |
The objective of this research is to produce new compounds effective against inflammatory orphan diseases including inflammatory bowel disease or Crohn disease. Production of new anti-inflammatory compounds was performed by targeting nuclear receptors, retinoid X receptors (RXRs) and retinoic acid receptors (RARs).As a result, RXR agonists were found to show anti-inflammatory activity against DSS-induced and TNBS induced mice colitis.
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[Journal Article] Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity.2009
Author(s)
Morishita K, Yakushiji N, Ohsawa F, Takamatsu K, Matsuura N, Makishima M, Kawahata M, Yamaguchi K, Tai A, Sasaki K, Kakuta H.
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Journal Title
Bioorg. Med. Chem.
Pages: 1001-1003
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