2009 Fiscal Year Final Research Report
Transcription factor Nrf2 as a defense mechanism against cadmium toxicity in vascular system
| Project/Area Number |
20790116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hokuriku University |
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Principal Investigator |
SHINKAI Yasuhiro Hokuriku University, 大学院・人間総合科学研究科, 助教 (10454240)
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| Project Period (FY) |
2008 – 2009
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| Keywords | カドミウム / Nrf2 / 血管内皮細胞 / メタロチオネイン |
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| Research Abstract |
Cadmium, a ubiquitous heavy metal, is an important industrial and environmental pollutant that can target the vascular endothelium. In this study, we investigated the participation of Nrf2 in cellular response to cadmium and protection against this metal in bovine aortic endothelial cells. Exposure of the cells to cadmium resulted in Nrf2 activation followed by up-regulated expression of antioxidant proteins. We found that the Nrf2/Keap1 system serves as a defense mechanism against cadmium toxicity through a positive regulation of metallothionein gene in vascular endothelial cells.
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[Journal Article] Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes.2010
Author(s)
Hirooka T, Fujiwara Y, Minami Y, Ishii A, Ishigooka M, Shinkai Y, Yamamoto C, Satoh M, Yasutake A, Eto K, Kaji T
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Journal Title
Toxicology In Vitro 24
Pages: 835-841
Peer Reviewed
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