2009 Fiscal Year Final Research Report
Investigation of peptidoglycan modification and its role in virulence of Salmonella enterica serovar Typhimurium.
| Project/Area Number |
20790119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
KAWANO Miyuki Doshisha Women's College of Liberal Arts, 薬学部, 特別任用助教 (10454498)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 微生物・感染症学 / マクロファージ / エンドトキシン / ペプチドグリカン / グラム陰性菌外膜 |
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| Research Abstract |
Salmonella Typhimurium LpxR potentially detoxifies lipid A by 3'-0-deacylation. The intracellular growth of the lpxR-null strain was lower than that of the wild-type strain, and the expression level of iNOS was enhanced in the cells infected with the lpxR-null strain. We also identified the candidate genes for peptidoglycan N-deacetylase in S.Typhimurium. The deletion of the gene also affected the intracellular growth. These results suggested that the cell wall modifications were important for the intracellular growth of S.Typhimurium within host cells.
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