2009 Fiscal Year Final Research Report
Mechanisms for the inhibitory effect of polycyclic aromatic hydrocarbons on androgen-dependent transcriptional activation
| Project/Area Number |
20790120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
SANADA Noriko Doshisha Women's College of Liberal Arts, 薬学部, 助教 (60411089)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 環境衛生学 / 内分泌撹乱物質 |
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| Research Abstract |
The aim of this study is to investigate the mechanism for the inhibitory effect of 3-methylcholanthrene (3MC) on 5α-dihydrotestosterone (DHT)-dependent transcriptional activation in human prostate cancer LNCaP cells. The results in this study suggest that complex formation between AhR and androgen receptor (AR), and binding of AhR to the AhR-binding site in the transcriptional regulatory region of androgen-regulated gene, a prostate specific antigen gene, play important roles in the inhibitory effect of 3MC on DHT-dependent transcriptional activation.
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