2009 Fiscal Year Final Research Report
Cross-talk of zinc transporter and Ca channels in cellular transport of cadmium
| Project/Area Number |
20790123
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
FUJISHIRO Hitomi Tokushima Bunri University, 薬学部, 助教 (10389182)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 中毒学 / カドミウム / 衛生 / 生体分子 / 輸送体 / 亜鉛 / カルシウムチャネル |
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| Research Abstract |
Cadmium(Cd) is a heavy metal widely distributed in the environment and causes adverse effects in a variety of organisms including humans. However, the mechanisms of cellular cadmium uptake and excretion have been poorly understood. It has been assumed that cellular Cd uptake is mediated by pathways for other essential elements such as Ca and Zn. The present study examined the involvement of Zn transporter and Ca channel in cellular Cd transport (influx and efflux) by using a cell line in which the expression of Zn transporter and Ca channel was changed.
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[Journal Article] The role of zinc transporters in cadmium and manganese transport in mammalian cells2009
Author(s)
Fujishiro, H., Okugaki, S., Kubota, K., Fujiyama, T., Miyataka, H., Himeno, S.
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Journal Title
J. Appl. Toxicol. 29(5)
Pages: 367-373
Peer Reviewed
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[Journal Article] lead acetate on the expression of metallothionein in the liver and kidney of mice2009
Author(s)
Yu, J., Fujishiro, H., Miyataka, H., Oyama, M.T., Hasegawa, T., Seko, Y., Miura, N., Himeno, S.
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Journal Title
Biol. Pharm. Bull. 32(6)
Pages: 1037-1042
Peer Reviewed
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