2009 Fiscal Year Final Research Report
Analaysis on iron acquision mechanisms and pathogenicity of opportunistic pathogens
| Project/Area Number |
20790124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Matsuyama University |
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Principal Investigator |
FUNAHASHI Atsuya Matsuyama University, 薬学部, 准教授 (60343646)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 鉄 / シデロフォア / 細菌 / 日和見感染菌 / acinetobactin / バイオフィルム |
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| Research Abstract |
In response to iron starvation, nosocomial Acinetobacter baumannii produces the siderophore, acinetobactin, and can transport acinetobactin-bound iron into the periplasm via its specific outer membrane receptor, BauA. In this study, I showed that A. baumannii was also capable of utilizing a variety of xenosiderophores produced by other microorganism as an iron source. Biofilms consist of bacteria attached to surfaces and encased in a polymeric matrix. I showed that iron and acinetobactin appear to mediate the control of biofilm formation.
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