2009 Fiscal Year Final Research Report
Feasibility study of RANKL subcellular trafficking as a novel therapeutic target for osteoporosis
| Project/Area Number |
20790129
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
HONMA Masashi The University of Tokyo, 医学部附属病院, 助教 (60401072)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 薬理学 / 生理学 / シグナル伝達 / 発現制御 / 生体分子 |
|---|
| Research Abstract |
We have found that OPG, which is previously recognized as a decoy receptor for RANKL, forms a complex with RANKL at the Golgi apparatus and the complex formation is necessary for Vps33a-mediated RANKL sorting to the lysosomes in osteoblastic cells. We have also found that RANKL localized at the lysosomes relocate to the cell surface in response to RANK stimulation. These processes can be novel therapeutic targets for osteoporosis.
|
