2009 Fiscal Year Final Research Report

Development of new therapy of steatohepatitis by Clostridium Butyricum

Research Project

Project/Area Number	20790131
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Medical pharmacy
Research Institution	Kanazawa University
Principal Investigator	NAGATA Naoto Kanazawa University, 薬学系, 助教 (70456408)
Project Period (FY)	2008 – 2009
Keywords	脂肪肝炎 / 薬物療法 / 脂質代謝
Research Abstract	We tested to treat atherogenic-diet (high cholesterol diet) induced steatohepatitis in mice by Clostridium Butyricum. After 4, 8, 16, and 32 weeks treatment, the atherogenic diet-induced steatosis, inflammation, and fibrosis were improved in the mice liver. We demonstrated that butyrate up-regulates fatty acid beta oxidation via activation AMP activated protein kinase and histone acetylation in vitro. Clostridium Butyricum may improve non-alcoholic steatohepatitis.