2009 Fiscal Year Final Research Report
Developmental research for measurement of acrolein and polyamine oxidase as markers for diagnosis of brain infarction
Project/Area Number |
20790143
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | Chiba Institute of Science |
Principal Investigator |
TOMITORI Hideyuki Chiba Institute of Science, 薬学部, 講師 (30337381)
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Project Period (FY) |
2008 – 2009
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Keywords | 生理活性物質 / 脳・神経 / バイオマーカー / 臨床化学 / 薬物治療・トキシコロジー |
Research Abstract |
Polyamines play important roles in cell proliferation and differentiation. However, acrolein that is highly toxic compound is produced by polyamine oxidation. In this study, new methods for measuring acrolein and polyamine oxidases, and molecular mechanism of acrolein toxicity on cell growth have been studied. New findings in this study have been described below.
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[Journal Article] Identification of acrolein-conjugated protein in plasma of patients with brain infarction. Biochem2010
Author(s)
Yoshida, M., Higashi, K., Jin, L., Machi, Y., Suzuki, T., Masuda, A., Dohmae, N., Suganami, A., Tamura, Y., Nishimura, K., Toida, T., Tomitori, H., Kashiwagi, K., Igarashi, K.
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Journal Title
Biophys. Res. Commun. 391
Pages: 1234-1239
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[Journal Article] Enhancement of the synthesis of RpoE and StpA by polyamines at the level of translation in Escherichia coli under heat shock conditions2009
Author(s)
Terui, Y., Higashi, K., Tabei, Y., Tomitori, H., Yamamoto, K., Ishihama, A., Igarashi, K., Kashiwagi, K.
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Journal Title
J. Bacteriol 191
Pages: 5348-5357
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[Journal Article] Acrolein, IL-6 and CRP as markers of silent brain infarction2009
Author(s)
Yoshida, M., Tomitori, H., Machi, Y., Katagiri, D., Ueda, S., Horiguchi, K., Kobayashi, E., Saeki, N., Nishimura, K., Ishii, I., Kashiwagi, K., Igarashi, K.
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Journal Title
Atherosclerosis 203
Pages: 557-562
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[Journal Article] Acrolein toxicity: Comparison with reactive oxygen species2009
Author(s)
Yoshida, M., Tomitori, H., Machi, Y., Hagihara, M., Higashi, K., Goda, H., Ohya, T., Niitsu, M., Kashiwagi, K., Igarashi, K.
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Journal Title
Biochem. Biophys. Res. Commun. 378
Pages: 313-318
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[Journal Article] Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-D-aspartate receptor2008
Author(s)
Han, X., Tomitori, H., Mizuno, S., Higashi, K., Full, C., Fukiwake, T., Terui, Y., Leewanich, P., Nishimura, K., Toida, T., Williams, K., Kashiwagi, K., Igarashi, K.
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Journal Title
J. Neurochem 107
Pages: 1566-1577
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[Presentation] Polyamine effect on protein synthesis and its mechanism2009
Author(s)
Kashiwagi, K., Terui, Y., Higashi, K., Okudaira, H., Ochiai, E., Tomitori, H., Nishimura, K., Yamamoto, K., Ishihama, A., Igarashi, K.
Organizer
Gordon Research Conference on Polyamines
Place of Presentation
Waterville Valley, NH, USA
Year and Date
2009-06-22
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